HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 46909016, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (2-Thienylmethyl)amine | HCID 34005 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 67133908 | HCID 67133908 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 46909016 | HCID 46909016 | — |
Reaction Steps
NEt3 was added to a solution of 323 mg (1.0 mmol) of 2-(4-(3-trifluoromethyl-phenyl)butyl)nicotinic acid (VB005), 113 mg (1.0 mmol) of 2-(aminomethyl)-thiophene and 381 mg (1.0 mmol) of HATU in THF (8 ml) and stirring was carried out for 4 d at RT. The mixture was then concentrated in vacuo. The residue was taken up in EA and washed with a 1M aq. NH4Cl sol. and a 1M aq. NaHCO3 sol. The organic phase was dried over MgSO4, filtered and concentrated in vacuo. The residue was purified by means of CC (EA/hex 3:1), yielding 221 mg (0.5 mmol, 53%). MS: m/z 419.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586755B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-2ee208dcfc084b86b2a1a702f4a68be8 |
| Source note | uspto-grants-2013_11 |