HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 4-Bromo-2-fluoro-3-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 3-Amino-2-fluorobenzotrifluoride | HCID 145569 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Bromo-2-fluoro-3-(trifluoromethyl)aniline | HCID 53669714 | — |
Reaction Steps
To a solution of 2-fluoro-3-trifluoromethylaniline (5.0 g, 28 mmol) in DMF (25 mL) is added a solution of NBS (5.0 g, 28 mmol) in DMF (25 mL). After 2.5 h, the reaction is partitioned between ether and saturated aqueous NaCl. The separated organic phase is washed twice with fresh saturated aqueous NaCl, dried over Na2SO4, and concentrated under reduced pressure to give 4-bromo-2-fluoro-3-trifluoromethylaniline as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586782B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-85a3cae27e104411bf6e315ad623247c |
| Source note | uspto-grants-2013_11 |