HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Ammonium Hydroxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 6-Chloro-2-fluoro-3-methylbenzoic acid | HCID 2773669 | — |
| Product | Ammonium Hydroxide | HCID 14923 | 36% |
| Product | 6-Chloro-2-fluoro-3-methylbenzamide | HCID 2773664 | — |
Reaction Steps
To 6-chloro-2-fluoro-3-methylbenzoic acid (10 g, 53 mmol) is added CH2Cl2 (60 mL), DMF (0.5 mL) and oxalyl chloride (9.25 mL, 106 mmol). The reaction mixture is allowed to stir until it reaches homogeneity and is then concentrated in vacuo. The residue is poured onto a 50:50 mixture of ice: 36% ammonium hydroxide to yield 6-chloro-2-fluoro-3-methylbenzamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586782B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-6dc6942cca3b4cc0b730150c345d5ce0 |
| Source note | uspto-grants-2013_11 |