HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl orthoacetate → Methyl 4-iodo-3-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl orthoacetate | HCID 15050 | — |
| Reactant | 4-Iodo-3-nitrobenzoic acid | HCID 11208598 | — |
| Product | Methyl 4-iodo-3-nitrobenzoate | HCID 297884 | 99% |
Reaction Steps
A solution of 4-iodo-3-nitrobenzoic acid (3 g, 10 mmol) in trimethyl orthoacetate (30 ml) is refluxed (˜110° C.) for 15 hours and then solvent is evaporated under reduced pressure. The 4-iodo-3-nitrobenzoic acid methyl ester is obtained as a yellow solid (3.11 g, 99% yield, 97.5% HPLC).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586792B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-473861520cee4a66bf941ec762f4d455 |
| Source note | uspto-grants-2013_11 |