HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 4-formyl-3-hydroxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Formyl-3-hydroxybenzoic acid | HCID 317508 | — |
| Product | Methyl 4-formyl-3-hydroxybenzoate | HCID 14395860 | 85% |
Reaction Steps
4-Formyl-3-hydroxybenzoic acid (5 g, 30 mmol) was suspended in methanol (70 mL), and treated with thionyl chloride (3.29 mL 45 mmol) dropwise. The mixture was heated to reflux overnight. Concentrated to dryness, and 50 mL of toluene was added, and concentrated again. The residue was recrystallized from ethyl acetate-hexane. A total of 4.8 g (85%) of methyl 4-formyl-3-hydroxybenzoate was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586574B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-d1f3f72c12ea46a299ff3eed9d2ccb52 |
| Source note | uspto-grants-2013_11 |