HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 58204559, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-[4-Cyano-1-(1-methylethyl)-1H-pyrazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-9-carboxylic acid | HCID 58204934 | — |
| Product | HCID 58204559 | HCID 58204559 | — |
Reaction Steps
Following Example 109, 2-(4-Cyano-1-isopropyl-1H-pyrazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-9-carboxylic acid from Example 16 was coupled with ammonia to give 138. Yield 27.8 mg (44%). MS (ESI): 363.1. 1H NMR (400 MHz, DMSO) δ 8.46 (d, J=8.4, 1H), 8.11 (s, 1H), 8.00 (d, J=4.7, 2H), 7.62 (dd, J=8.4, 1.5, 1H), 7.57 (d, J=1.4, 1H), 7.44 (s, 1H), 5.46 (dt, J=13.1, 6.5, 1H), 4.59 (dd, J=17.5, 4.8, 4H), 1.48 (d, J=6.6, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586574B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-a80f73977e78474fa9f587ff0007bf4e |
| Source note | uspto-grants-2013_11 |