HRID20444

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)N[C@@H](Cc1cc(F)cc(OCc2ccccc2)c1)[C@H](O)[C@H]1CO[C@@H](OCC(C)(C)C)[C@H](C)N1C(=O)OC(C)(C)C

HCID68561775

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N[C@@H](Cc1cc(O)cc(F)c1)[C@H](O)[C@H]1CO[C@@H](OCC(C)(C)C)[C@H](C)N1C(=O)OC(C)(C)C

HCID68560537

未命名化合物

收率 94.9%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Stir (2R,3S,5R)-5-[(1S,2S)-2-acetylamino-3-(3-benzyloxy-5-fluoro-phenyl)-1-hydroxy-propyl]-2-(2,2-dimethyl-propoxy)-3-methyl-morpholine-4-carboxylic acid tert-butyl ester (0.81 g, 1.34 mmol) and 10% palladium on carbon (0.50 g, 1.41 mmol) in ethanol (20 mL) under a hydrogen atmosphere for 3 hours. Filter and concentrate to give 0.652 g (94.7%) of the desired compound as a white solid.

WORKUP

后处理

filtrationFilter
concentrationconcentrate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-fa64f9f3a0154815880074c64d787898
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07745438B2
来源说明: uspto-grants-2010_06

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[C@@H:13]([C@@H:14]([OH:36])[C@@H:15]([NH:32][C:33](=[O:35])[CH3:34])[CH2:16][C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([O:24]CC3C=CC=CC=3)[CH:18]=2)[CH2:12][O:11][C@@H:10]([O:37][CH2:38][C:39]([CH3:42])([CH3:41])[CH3:40])[C@@H:9]1[CH3:43])=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].C(O)C>[C:1]([O:5][C:6]([N:8]1[C@@H:13]([C@@H:14]([OH:36])[C@@H:15]([NH:32][C:33](=[O:35])[CH3:34])[CH2:16][C:17]2[CH:18]=[C:19]([OH:24])[CH:20]=[C:21]([F:23])[CH:22]=2)[CH2:12][O:11][C@@H:10]([O:37][CH2:38][C:39]([CH3:42])([CH3:41])[CH3:40])[C@@H:9]1[CH3:43])=[O:7])([CH3:3])([CH3:4])[CH3:2]