HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3-(Chloromethyl)-8-methyl-2-o-tolylquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (8-Methyl-2-o-tolylquinolin-3-yl)methanol | HCID 57707986 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-(Chloromethyl)-8-methyl-2-o-tolylquinoline | HCID 57556173 | — |
Reaction Steps
Prepared according to Procedure C using (8-methyl-2-o-tolylquinolin-3-yl)-methanol (670 mg, 2.5 mmol) and SOCl2 (0.91 mL, 5 eq) in CHCl3 (10 mL). After isolation, the resultant oil was carried on crude without purification for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586739B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-831fbfa52cc64820a9429ecfb1388637 |
| Source note | uspto-grants-2013_11 |