Diisopropylethylamine → HCID 178505917, compound

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Reaction Steps

Prepared according to Procedure H using (8-chloro-2-(3,5-difluorophenyl)-quinolin-3-yl)methanamine (0.105 g, 0.345 mmol), 6-chloropurine (0.064 g, 0.41 mmol, 1.2 eq) and DIEA (0.70 mmol, 2.0 eq) in n-butanol (3 mL). N-((8-chloro-2-(3,5-difluorophenyl)quinolin-3-yl)methyl)-9H-purin-6-amine [PI3Kδ IC50=76 nM] was obtained after purification as a white solid. 1H-NMR (MeOD) 8 ppm 8.48 (s, 1 H), 8.35 (s, 1 H), 8.24 (s, 1 H), 7.86-7.94 (m, 2 H), 7.52-7.61 (m, 1 H), 7.27-7.35 (m, 2 H), 6.96-7.06 (m, 1 H), 4.73 (d, J=5.71, 2 H), Mass Spectrum (ESI) m/e=423 (M+1).

Provenance & Evidence