Diisopropylethylamine → HCID 178505394, compound

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Reaction Steps

Prepared according to Procedure H using (2-(2-chlorophenyl)-6,7-difluoro-quinolin-3-yl)methanamine (0.080 g, 0.279 mmol), 6-chloropurine (0.065 g, 0.42 mmol, 1.5 eq) and DIEA (0.56 mmol, 2.0 eq) in n-butanol (3 mL). N-((2-(2-chlorophenyl)-6,7-difluoroquinolin-3-yl)methyl)-9H-purin-6-amine [PI3Kδ IC50=551 nM] was obtained after purification as a white solid. 1H-NMR (MeOD) δ ppm 8.46 (s, 1 H), 8.13 (s, 1 H), 8.09 (s, 1 H), 7.83-7.94 (m, 3 H), 7.49-7.55 (m, 2 H), 7.41-7.48 (m, 1 H), 7.35-7.41 (m, 1 H), 4.89-4.85 (m, 2H), Mass Spectrum (ESI) m/e=423 (M+1).

Provenance & Evidence