HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → Benzoic acid, 4-fluoro-2-phenoxy-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Methyl 2-bromo-4-fluorobenzoate | HCID 7210837 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Benzoic acid, 4-fluoro-2-phenoxy-, methyl ester | HCID 67144536 | — |
Reaction Steps
Methyl 2-bromo-4-fluorobenzoate (1 g), phenol (0.565 g), cesium carbonate (1.96 g), copper(I) triflate toluene complex (0.087 g), and ethyl acetate (0.034 mL) in toluene (12 mL) was stirred at 110° C. for 24 hours. The reaction was cooled and chromatographed on silica gel with 5% ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586754B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-5ba7735cc82946409ca87b31ff1e2375 |
| Source note | uspto-grants-2013_11 |