HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → ethyl 2-(1H-indazol-5-yloxy)-4-fluorobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 1H-Indazol-5-ol | HCID 101438 | — |
| Reactant | Benzoic acid, 2,4-difluoro-, ethyl ester | HCID 2737170 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | ethyl 2-(1H-indazol-5-yloxy)-4-fluorobenzoate | HCID 67225497 | — |
Reaction Steps
Ethyl 2,4-difluorobenzoate (1.14 g), K3PO4 (1.30 g) and 5-hydroxyindazole (0.90 g) were stirred at 110° C. in diglyme (12 mL) for 24 hours. The reaction was cooled and poured into ether. The solution was washed three times with 1M NaOH solution, and brine, and dried. The solution was then concentrated, and the crude product was chromatographed on silica gel with 20% ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586754B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-8a478bcf6a2942db8752a3bb25ca63ac |
| Source note | uspto-grants-2013_11 |