HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → 3-Cyano-4-fluorobenzene-1-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 3-Cyano-4-fluorobenzenesulfonyl chloride | HCID 2778908 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 3-Cyano-4-fluorobenzene-1-sulfonamide | HCID 25139897 | — |
Reaction Steps
Concentrated ammonium hydroxide (28% solution in water, 3.17 mL) was cooled to 0° C. and 3-cyano-4-fluorobenzene-1-sulfonyl chloride (1.00 g) was added. The solution was mixed at 0° C. for four minutes. 4M HCl (10 mL) was added slowly and the solution was extracted with ethyl acetate. The extract was dried on brine and anhydrous sodium sulfate and the solvent removed under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586754B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-0e1b1ae387274e3f9fd3df56561940aa |
| Source note | uspto-grants-2013_11 |