HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | tert-butyl N-[1-(oxan-4-yl)piperidin-4-yl]carbamate | HCID 45792109 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine | HCID 22562145 | — |
Reaction Steps
A solution of EXAMPLE 173A (52.57 g) in dichloromethane (900 mL) was treated with 4M HCl (462 mL), mixed vigorously at room temperature for 16 hours and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08586754B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-af1b8d05ac49498a85fc1d4f98632aed |
| Source note | uspto-grants-2013_11 |