HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2045012Generated: October 26, 2026
Water → 3-Nitro-4-(1-(tetrahydro-2h-pyran-4-yl)piperidin-4-ylamino)benzenesulfonamide
https://huagongshe.com/reaction/2045012
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Chloro-3-nitrobenzenesulfonamide | HCID 7324 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine | HCID 22562145 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Nitro-4-(1-(tetrahydro-2h-pyran-4-yl)piperidin-4-ylamino)benzenesulfonamide | HCID 67126384 | — |
Reaction Steps
A mixture of EXAMPLE 173B (22.12 g), water (43 mL), and triethylamine (43.6 mL) in 1,4-dioxane (300 mL) was stirred at room temperature until EXAMPLE 173B completely dissolved. The solution was then treated with 4-chloro-3-nitrobenzenesulfonamide, heated at 90° C. for 16 hours, cooled and concentrated. 10% methanol in dichloromethane was added, and the solution was stirred vigorously at room temperature until a fine suspension existed and the mixture was filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08586754B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-72b145c9bf5e4a9ca2a3592951931f0a |
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| Source note | uspto-grants-2013_11 |
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