Diisopropylethylamine → HCID 67439889, compound

Participants

Reaction Steps

To s solution of 2-(4-fluoro-3-nitrophenyl)-3,3-dimethyl-1,2,3,4-tetrahydroquinoline-6-carboxy late (150 mg, 0.46 mmol) and N,N-diisopropylethylamine (0.15 mL, 0.91 mmol) in dichloro methane (10 mL) was added picolinoyl chloride (77 mg, 0.54 mmol) with ice cooling. Upon completion of addition, the resultant mixture was allowed to stir for 20 h. Solvent was removed in vacuo and the residue was purified by column chromatography (petroleum ether:ethyl acetate=3:1) to afford 84 mg of methyl 2-(4-fluoro-3-(picolinamido)phenyl)-3,3-dimethyl-1,2,3,4-tetrahydroquinoline-6-carboxylate. Yield: 42.4%.

Provenance & Evidence