Sodium Hydroxide → HCID 58476206, compound

Participants

Reaction Steps

A mixture of methyl 3,3-dimethyl-2-(3-(1-methylpyrrolidin-3-ylcarbamoyl)phenyl)-1,2,3,4-tetrahydroquinoline-8-carboxylate (76 mg, 0.18 mmol) in methanol (2.7 mL) and sodium hydroxide aqueous solution (1M, 2.34 mL, 2.34 mmol) was heated to reflux for 1.5 h, LC-MS showed the reaction was complete. The solvent was removed in vacuo and the residue was acidified with 1M hydrochloric acid solution until lots of white solid precipitated, which was collected by filtration and washed with water, dried in vacuo to afford 28 mg of 3,3-dimethyl-2-(3-(1-methylpyrrolidin-3-ylcarbamoyl)phenyl)-1,2,3,4-tetrahydroquinoline-8-carboxylic acid as a white solid. Yield: 38%. MS (ESI+APCI) M+1=408.2.

Provenance & Evidence