Potassium vinyltrifluoroborate → HCID 66896108, compound

Participants

Reaction Steps

Potassium trifluoro(vinyl)borate (68 mg, 0.513 mmol), TEA (0.071 mL, 0.513 mmol) and PdCl2(dppf)-CH2Cl2 adduct (28 mg, 0.034 mmol) were added in sequence to a solution of methyl (4R)-4-[(3-chloroquinoxalin-2-yl)oxy]-1-[(25)-2-cyclopentyl-2-({[(35)-3-(pent-4-en-1-yloxy)pyrrolidin-1-yl]carbonyl}amino)acetyl]-L-prolinate (210 mg, 0.342 mmol) in EtOH (4 mL). The resulting mixture was refluxed for 1 h, then concentrated under reduced pressure to give a residue that was purified on silica gel (gradient elution from 10% to 50% AcOEt in petroleum ether) to afford the title compound (163 mg, 79%) as a solid. LCMS (ES+) m/z 606 (M+H)+.

Provenance & Evidence