HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2045767Generated: October 30, 2026
Acetal → 1,3,5-Triazine-2,4-diamine, 3,6-dihydro-N2,N2,6-trimethyl-, hydrochloride (1:1)
https://huagongshe.com/reaction/2045767
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetal | HCID 7765 | — |
| Reactant | Metformin Hydrochloride | HCID 14219 | — |
| Catalyst | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| Solvent | Isobutanol | HCID 6560 | — |
| Product | 1,3,5-Triazine-2,4-diamine, 3,6-dihydro-N2,N2,6-trimethyl-, hydrochloride (1:1) | HCID 10176486 | 77.6% |
Reaction Steps
Comparative experiment) A mixture of 250.2 g of metformin hydrochloride, 213.6 g of acetaldehyde diethyl acetal and 12.5 g of toluene-4-sulfonic acid monohydrate in 500 ml of isobutanol was heated under reflux for 40 hours. Some of the solvent was removed by distillation. The mixture was cooled to 10° C., and the white precipitate was separated off, giving 224.7 g (77.4%) of 4-amino-3,6-dihydro-2-dimethylamino-6-methyl-1,3,5-triazine hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08592370B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-105ac39c82544dfabf71cda3f02028cd |
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| Source note | uspto-grants-2013_11 |
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