Trifluoromethanesulfonic acid → HCID 71118335, compound

Participants

Reaction Conditions

Reaction Steps

A 500-mL, three-necked, round-bottomed flask was charged with cis-6-(4-fluorophenyl)-6-azabicyclo[3.2.0]heptan-7-one (racemic 17DP) (26.5 g, 129 mmol) and 250 mL of dichloroethane. The reaction mixture was cooled at 5° C. while triflic acid was added via syringe over 10 min. The reaction mixture was stirred at 50° C. for 4 h. The reaction mixture was cooled to room temperature with an ice-water bath and then quenched with saturated sodium bicarbonate to adjust the pH to 10. The organic layer was separated, washed with brine, dried over MgSO4, filtered, and concentrated to give 26.5 g of a 90:10 mixture of the title compound as a brown semi-solid.

Provenance & Evidence