Potassium Carbonate → HCID 50943967, compound

Participants

Reaction Steps

The title compound from example 3 (65 mg, 0.12 mmol) was dissolved in acetone (1 mL) and water (0.5 mL). To the solution was added urea hydrogen peroxide (110 mg, 1.2 mmol) followed by K2CO3 (5 mg, 0.036 mmol) and the reaction stirred at room temperature for 2 h, whereupon the reaction was found to be mostly complete by LC-MS. The reaction was poured into water and extracted with EtOAc. The organic layer was dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse-phase HPLC eluting with 10-90% water/acetonitrile/0.1% TFA. The title compound (37 mg, 54% yield) was obtained as a white solid (free-based with K2CO3).

Provenance & Evidence