Potassium Carbonate → HCID 50943969, compound

Participants

Reaction Steps

To a suspension of the title compound from example 4 (63 mg, 0.11 mmol) in t-butanol (1 mL) was added 1M NaOH (0.28 mL) and the reaction stirred at room temperature for 2 h, followed by heating to 80° C. for 2 h. The reaction was cooled to room temperature and partitioned between ethyl acetate and pH 8 buffer solution. The organic layer was dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse-phase HPLC eluting with 10-90% water/acetonitrile/0.1% TFA. The title compound (40 mg, 63% yield) was obtained as a white solid (free-based with K2CO3).

Provenance & Evidence