4,4-Difluorocyclohexanecarboxylic acid → HCID 50942944, compound

HRID 2045804Notes

Reaction equation

HRID 2045804 reaction equation
[F:1][C:2]1([F:11])[CH2:7][CH2:6][CH:5]([C:8]([OH:10])=O)[CH2:4][CH2:3]1.[CH3:12][C:13]([C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)([CH2:16][CH2:17][N:18]1[C@H:23]2[CH2:24][CH2:25][C@@H:19]1[CH2:20][CH:21]([N:26]1[C:30]([CH:31]([CH3:33])[CH3:32])=[N:29][N:28]=[C:27]1[CH3:34])[CH2:22]2)[CH2:14][NH2:15]>>[F:11][C:2]1([F:1])[CH2:3][CH2:4][CH:5]([C:8]([NH:15][CH2:14][C:13]([CH3:12])([C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[CH2:16][CH2:17][N:18]2[C@H:23]3[CH2:24][CH2:25][C@@H:19]2[CH2:20][CH:21]([N:26]2[C:30]([CH:31]([CH3:33])[CH3:32])=[N:29][N:28]=[C:27]2[CH3:34])[CH2:22]3)=[O:10])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 27791364,4-Difluorocyclohexanecarboxylic acidHCID 70805136HCID 70805136, compound2×

Product 1

HCID 50942944HCID 50942944, compound

Procedure

The title compound was synthesized by coupling 4,4-difluorocyclohexanecarboxylic acid and (2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)amine (intermediate 24) as described in example 21.

Sources & evidence

ORD record
ord-9acff176d2c941c6a954df1d12e11aba
Source dataset
uspto-grants-2013_11
Patent number
US08592395B2

Reaction notes

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