Benzenesulfonyl chloride → HCID 50942945, compound

Participants

Reaction Steps

To a solution of intermediate 24 (158 mg, 0.4 mmol) in CH2Cl2 (4 mL) was added diisopropylethylamine (0.175 mL, 1.0 mmol) followed by phenylsulfonyl chloride (0.065 mL, 0.5 mmol) and the solution stirred at room temperature under nitrogen atmosphere for 18 h. The reaction was concentrated in vacuo and purified by silica gel chromatography eluting with 0-5% methanol/CH2Cl2 to give the title compound (150 mg, 70%) as a white solid.

Provenance & Evidence