HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2045816Generated: October 31, 2026
Piperazine → 7-ethyl-2-piperazin-1-yl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine
https://huagongshe.com/reaction/2045816
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-chloro-7-ethyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine | HCID 58071589 | — |
| Product | 7-ethyl-2-piperazin-1-yl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine | HCID 58071600 | 52.6% |
Reaction Steps
3 g 2-chloro-7-ethyl-6,7,8,9-tetrahydro-5H-pyrazino[2,3-d]azepine are combined with 23.3 g piperazine and the mixture is heated to 145° C. for 5 hours. Excess piperazine is distilled off and the residue is treated with dichloromethane and methanol. Any product precipitated is suction filtered and purified by chromatography (Alox, dioxane/toluene/methanol/NH4OH 50/20/20/2). 1.95 g product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08592400B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-a987bff9d5e3414c885614ff03dc2139 |
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| Source note | uspto-grants-2013_11 |
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