HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Ethoxycarbonylmethylphenylboronic acid → (4'-{4-[(R)-1-(2-Chloro-phenyl)-ethoxycarbonylamino]-5-methyl-isoxazol-3-yl}-biphenyl-4-yl)-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Ethoxycarbonylmethylphenylboronic acid | HCID 45790002 | — |
| Reactant | [3-(4-bromo-phenyl)-5-methyl-isoxazol-4-yl]-carbamic acid (R)-1-(2-chloro-phenyl)-ethyl ester | HCID 68184987 | — |
| Product | (4'-{4-[(R)-1-(2-Chloro-phenyl)-ethoxycarbonylamino]-5-methyl-isoxazol-3-yl}-biphenyl-4-yl)-acetic acid | HCID 50923256 | — |
Reaction Steps
Prepared according to the procedure described in Example 1, Step 3 using the following starting materials: [3-(4-bromo-phenyl)-5-methyl-isoxazol-4-yl]-carbamic acid (R)-1-(2-chloro-phenyl)-ethyl ester and (4-ethoxycarbonylmethylphenyl)boronic acid, pinacol ester. Mass spectometric data [M+H]=491.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592402B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-014d643f417d463b8a5ca5f834ec3eba |
| Source note | uspto-grants-2013_11 |