Piperidin-4-ol → HCID 46916505, compound

Participants

Reaction Steps

A mixture of 2-bromo-N-(3-(quinoxalin-2-yl)phenyl)acetamide (93 mg, 0.272 mmol) and 4-hydroxypiperidine (138 mg, 1.35 mmol) in isopropanol (5 mL) was heated at reflux for 1 h. The solvent was evaporated in vacuo and the crude reaction mixture was purified by preparative LCMS to afford 2-(4-hydroxypiperidin-1-yl)-N-(3-(quinoxalin-2-yl)phenyl)acetamide (26 mg, 26% yield). LCMS calculated for C21H22N4O2 (M+H): 363.43. found 363.40. 1H-NMR (CD3CN, 400 Mhz) δH: 9.55 (1H, br.), 9.25 (1H, s), 8.40 (1H, m), 8.00-8.05 (2H, m), 7.85-7.90 (1H, m), 7.65-7.80 (3H, m), 7.40-7.48 (1H, m), 3.65 (1H, m), 3.22 (2H, s), 2.85-3.15 (OH and 2H, br. and m), 2.40-2.50 (2H, m), 1.82-1.92 (2H, m), 1.55-1.68 (2H, m).

Provenance & Evidence