反应详情

Manganese dioxide (12.0 g) is added portion wise to a solution of {5-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophen-2-yl}-methanol (4.63 g) in dichloromethane (80 ml). After 2 hours at room temperature, the reaction mixture is filtered through a plug of Celite and the filtration cake is washed with dichloromethane. The filtrate is concentrated in vacuo to yield 5-[5-(3,5-dichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-3-methyl-thiophene-2-carbaldehyde (4.25 g) as a yellowish solid. The crude product obtained is used without further purification. MS (HPLC/MS): 408 (MH+). Retention time: 2.16 min.

1. filtrationthe reaction mixture is filtered through a plug of Celite
2. washthe filtration cake is washed with dichloromethane
3. concentrationThe filtrate is concentrated in vacuo