HCID 86681293, compound → HCID 86681295, compound

Participants

Reaction Steps

MnO2 (1.75 g) is added portion wise to a solution of {3-methyl-5-[5-(3,4,5-trichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-furan-2-yl}-methanol (1.72 g) in dichloromethane (40 ml). After 16 hours at room temperature, additional MnO2 (4.37 g) is added portion wise and the reaction mixture is stirred at room temperature for a further 3 hours. The reaction mixture is filtered through a plug of Celite and the filtration cake is washed with dichloromethane. The filtrate is concentrated in vacuo to yield 3-methyl-5-[5-(3,4,5-trichloro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-furan-2-carbaldehyde (1.28 g) as a light yellow foam. The crude product obtained is used without further purification. MS (HPLC/MS): 426 (MH+). Retention time: 2.21 min.

Provenance & Evidence