Hydrochloric Acid → HCID 44315704, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 1 g (3.74 mmol) of 3-(3-Methoxy-phenyl)-4H-benzo[f][1,4]oxazepin-5-one in dioxane (20 mL), 0.225 g (5.6 mmol) of sodium hydride (60% dispersion in mineral oil) were added under strictly oxygen-free atmosphere and the mixture was heated at 100° C. for 45 min. After cooling to room temperature, 2N hydrochloric acid was added till pH 1 then water was added until complete precipitation of the product was reached. The solid was filtered, washed with water and dried in vacuo, affording 0.82 g of the title compound (82%).

Provenance & Evidence