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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2045972Generated: October 30, 2026

Hydrochloric Acid → 2-(3-Amino-propylamino)-N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-acetamide hydrochloride

https://huagongshe.com/reaction/2045972

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant(3-{[(6-Oxo-5,6-dihydro-phenanthridin-2-ylcarbamoyl)-methyl]-amino}-propyl)-carbamic acid tert-butyl esterHCID 66819479—
SolventDichloromethaneHCID 6344—
Solvent1,4-DioxaneHCID 31275—
Product2-(3-Amino-propylamino)-N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-acetamide hydrochlorideHCID 6681963797%

Reaction Steps

32 mg of (3-{[(6-oxo-5,6-dihydro-phenanthridin-2-ylcarbamoyl)-methyl]-amino}-propyl)-carbamic acid tert-butyl ester (0.075 mmol) were dissolved in dichloromethane (1 mL) and 4N hydrochloric acid in dioxane (1 mL) was added. The reaction mixture was stirred at room temperature overnight and then evaporated, affording 32 mg (97% yield) of the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08592416B2
Source datasetuspto-grants-2013_11
ORD IDord-e16f571ec2294fd7b8ac922a8abcacb1
Source noteuspto-grants-2013_11