HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 58109228, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | Ethanaminium, N,N,N-triethyl-, fluoride (1:1) | HCID 69582 | — |
| Reactant | HCID 178461657 | HCID 178461657 | — |
| Product | HCID 58109228 | HCID 58109228 | — |
Reaction Steps
The title compound was prepared from (R)-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-3-((S)-1-(4-(2-hydroxypyrimidin-4-yl)phenyl)ethyl)-1,3-oxazinan-2-one by treatment with (i) TBSCl, (ii) NaH, MeI and (iii) Et4NF. LC-MS Method 2 tR=1.079 min, m/z=466.2; 1H NMR (CD3OD) 1.20 (m, 3H), 1.49 (d, 3H), 1.78-1.91 (m, 2H), 2.08 (s, 1H), 2.14 (m, 1H), 2.28 (m, 1H), 2.39 (m, 1H), 3.07 (m, 1H), 3.36 (m, 3H), 3.50 (s, 3H), 4.50 (s, 2H), 5.49 (m, 1H), 6.90 (d, 1H), 6.95-7.08 (m, 4H), 7.21 (m, 2H), 7.80 (d, 2H), 8.06 (d, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592410B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-093ed36df59a4b26b822873eec036149 |
| Source note | uspto-grants-2013_11 |