HRID2046014

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1cc(-c2ccc([C@H](C)N3CC[C@](CC(C)(C)O)(c4ccccc4)OC3=O)cc2)nn(C)c1=O

HCID42605499

未命名化合物

HCID58109513

未命名化合物

PRODUCTS

生成物

结构：C[C@@H](c1ccc(-c2ccc(=O)n(CC3CC3)n2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O

HCID42605500

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 3-{(S)-1-[4-(1,5-dimethyl-6-oxo-1,6-dihydro-pyridazin-3-yl)-phenyl]-ethyl}-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one and 6-chloro-2-(cyclopropylmethyl)pyridazin-3(2H)-one following a procedure analogous to that described in Example 17. Mass spectrum (ESI+): m/z=502 [M+H]+

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-91f8104f174648aca5ed8bf5c492f50c
来源数据集: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08592410B2
来源说明: uspto-grants-2013_11

反应 SMILES

[CH3:1][N:2]1[C:7](=[O:8])[C:6](C)=[CH:5][C:4]([C:10]2[CH:15]=[CH:14][C:13]([C@@H:16]([N:18]3[CH2:23][CH2:22][C@:21]([CH2:30][C:31]([OH:34])([CH3:33])[CH3:32])([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[O:20][C:19]3=[O:35])[CH3:17])=[CH:12][CH:11]=2)=[N:3]1.ClC1C=CC(=O)N(C[CH:44]2[CH2:46][CH2:45]2)N=1>>[CH:44]1([CH2:1][N:2]2[C:7](=[O:8])[CH:6]=[CH:5][C:4]([C:10]3[CH:11]=[CH:12][C:13]([C@@H:16]([N:18]4[CH2:23][CH2:22][C@:21]([CH2:30][C:31]([OH:34])([CH3:33])[CH3:32])([C:24]5[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=5)[O:20][C:19]4=[O:35])[CH3:17])=[CH:14][CH:15]=3)=[N:3]2)[CH2:46][CH2:45]1