HCID 66615069, compound → HCID 46199361, compound

Participants

Reaction Steps

A solution of the product of Step E (0.05 g; 0.129 mmol) in 60% TFA in CH2Cl2 (5 ml) was refluxed for 2 h, cooled to room temperature then diluted to 7 ml with EtOH. The resulting mixture was evaporated to dryness under reduced pressure kept in vacuo for 1 h. The residue was treated dissolved in EtOH (2 ml) and 3 drops of concentrated NH4OH was added. The resulting mixture was partially concentrated under reduced pressure and the precipitate, formed was filtered off, washed with Et2O and dried to give the titled compound (0.02 g; 47%) as colourless solid. 1H-NMR (CD3OD+CDCl3) 7.07 (d, 2H, J=8.6 Hz); 6.86 (d, 2H, J=8.6 Hz); 4.63 (s, CD3OH); 3.58 (s, 2H); 3.38 (m, 8H); 2.49 (t, 2H, J=7.8 Hz); 1.53 (m, 2H); 1.24 (m, 10H); 0.83 (m, 3H).

Provenance & Evidence