Ethyl 3-(3-(4-octylphenyl)ureido)propanoate → HCID 46199514, compound

HRID 2046048Notes

Reaction equation

HRID 2046048 reaction equation
[CH2:1]([C:9]1[CH:25]=[CH:24][C:12]([CH2:13][NH:14][C:15](=[O:23])[NH:16][CH2:17][C:18]([O:20]CC)=[O:19])=[CH:11][CH:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C(C1C=CC(NC(=O)NCCC(OCC)=O)=CC=1)CCCCCCC>>[CH2:1]([C:9]1[CH:10]=[CH:11][C:12]([CH2:13][NH:14][C:15](=[O:23])[NH:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:24][CH:25]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 66615004Ethyl 3-(3-(4-octylphenyl)ureido)propanoateHCID 66615075HCID 66615075, compound

Product 1

HCID 46199514HCID 46199514, compoundYield 87%

Procedure

When the product of Step A was substituted for ethyl 3-(3-(4-octylphenyl)ureido)propanoate in Example 11, Step B, the identical process afforded the title compound in 87% yield, as a colourless solid. 1H-NMR (CDCl3+CD3OD) 7.15 (d, 2H, J=8 Hz); 7.07 (d, 2H, J=8 Hz); 4.63 (CD3OH); 4.26 (s, 2H); 3.86 (s, 2H); 2.52 (t, 2H, J=7.8 Hz); 1.54 (m, 2H); 1.22 (m, 10H); 0.83 (t, 3H, J=7 Hz).

Sources & evidence

ORD record
ord-8b336882c02547dabe4caa5d3674e475
Source dataset
uspto-grants-2013_11
Patent number
US08592399B2

Reaction notes

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