HCID 66615069, compound → HCID 46199515, compound

HRID 2046051Notes

Reaction equation

[CH2:1]([C:9]1[CH:29]=[CH:28][C:12]([CH2:13][N:14]2[CH2:18][CH2:17][N:16]([CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[C:15]2=[O:27])=[CH:11][CH:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C(C1C=CC(N2CCN(CC(OC(C)(C)C)=O)CC2)=CC=1)CCCCCCC>>[CH2:1]([C:9]1[CH:29]=[CH:28][C:12]([CH2:13][N:14]2[CH2:18][CH2:17][N:16]([CH2:19][C:20]([OH:22])=[O:21])[C:15]2=[O:27])=[CH:11][CH:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

Reactant 2

HCID 66615069HCID 66615069, compound

HCID 86660605HCID 86660605, compound

Product 1

HCID 46199515HCID 46199515, compoundYield 46%

Procedure

When the product of Step B was substituted for tert-butyl 2-(4-(4-octylphenyl)piperazin-1-yl)acetate in Example 9, Step F, the identical process afforded the title compound in 46% yield, as a colourless solid. 1H-NMR (CDCl3+CD3OD) 7.0 (m, 4H); 4.42 (s, 2H); 3.72 (s, 2H); 3.31 (m, 2H); 3.11 (m, 2H); 2.44 (t, 2H, J=7.8 Hz); 1.43 (m, 2H); 1.13 (m, 10H); 0.73 (t, 3H, J=7 Hz).

Sources & evidence

ORD record: ord-f4eb78eb085b4e75941181858652e3a1
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592399B2

Reaction notes

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