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3-Butyn-1-OL → 4-((6-Methoxybenzofuran-2-yl)ethynyl)phenyl acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Butyn-1-OL | HCID 13566 | — |
| 反応物 | 4-Iodophenylacetate | HCID 141793 | — |
| 反応物 | 4-Bromo-N-(6,6-dimethylbicyclo[3.1.1]heptan-2-yl)benzene sulfonamide | HCID 66614941 | — |
| 反応物 | 2-Ethynyl-6-methoxybenzofuran | HCID 71741760 | — |
| 生成物 | 4-((6-Methoxybenzofuran-2-yl)ethynyl)phenyl acetate | HCID 66614870 | 56% |
反応手順
When 4-iodophenyl acetate and 2-ethynyl-6-methoxybenzofuran were substituted for 4-bromo-N-(6,6-dimethylbicyclo [3.1.1]heptan-2-yl)benzene sulphonamide and but-3-yn-1-ol respectively in Example 18, Step B, the similar process afforded the title compound in 56% yield, as creamy paste. 1H-NMR (CDCl3) 7.56 (d, 2H, J=8.67 Hz); 7.41 (d, 1H, J=8.58 Hz); 7.10 (d, 2H, J=8.7 Hz); 6.97 (d, 1H, J=1.92 Hz); 6.9 (s, 1H); 6.88 (bd, 1H, J=8.61 Hz); 3.85 (5, 3H); 2.3 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08592399B2 |
| 出典データセット | uspto-grants-2013_11 |
| ORD ID | ord-cbd77d25cb59413296ace0f58e7d9bf4 |
| 出典メモ | uspto-grants-2013_11 |