HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromobenzaldehyde → 4-(4-Oxo-4-(3,4,5-trimethoxyphenyl)but-2-en-2-yl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromobenzaldehyde | HCID 70741 | — |
| Reactant | 5-Hydroxymethylthiophene-2-boronic acid | HCID 4374265 | — |
| Reactant | 3-Bromo-1-(3,4,5-trimethoxyphenyl)but-2-en-1-one | HCID 86660614 | — |
| Product | 4-(4-Oxo-4-(3,4,5-trimethoxyphenyl)but-2-en-2-yl)benzaldehyde | HCID 86660615 | 81% |
Reaction Steps
When the product of Step A and 4-carbaldehyde-boronic acid were substituted for 5-(hydroxymethyl)thiophen-2-ylboronic acid and 4-bromobenzaldehyde, respectively, in Example 22, Step A, the similar process afforded the title compound in 81% yield, as creamy gum. 1H-NMR (CDCl3) 10.05 (s, 1H); 7.92 (d, 2H, J=8.25 Hz); 7.68 (d, 2H, J=8.28 Hz); 7.23 (s, 2H); 7.10 (s, 1H); 3.91 (s, 9H); 2.55 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592399B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-0951a686fb344904a88ce52b5267bff0 |
| Source note | uspto-grants-2013_11 |