tert-butyl N-((2R)-1-hydroxypropan-2-yl)carbamate → HCID 67973726, compound

HRID 2046171Notes

Reaction equation

HRID 2046171 reaction equation
C(OC(=O)N[C@H](C)CO)(C)(C)C.C(OC(C1NN=C(COC2C=CC=CC=2)C=1)=O)C.C(OC([C:36]1[N:37]([CH2:49][CH:50]([NH:52][C:53]([O:55]C(C)(C)C)=O)[CH3:51])[N:38]=[C:39]([CH2:41][O:42][C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)[CH:40]=1)=O)C.O(CC1C=C2C(=O)NCCN2N=1)C1C=CC=CC=1>>[CH3:51][C@H:50]1[CH2:49][N:37]2[N:38]=[C:39]([CH2:41][O:42][C:43]3[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=3)[CH:40]=[C:36]2[C:53](=[O:55])[NH:52]1

Participants

5

Reactant 4

HCID 13200309tert-butyl N-((2R)-1-hydroxypropan-2-yl)carbamateHCID 57411799HCID 57411799, compoundHCID 67958408ethyl 1-{2-[(tert-butoxycarbonyl)amino]propyl}-3-(phenoxymethyl)-1H-pyrazole-5-carboxylateHCID 178469067HCID 178469067, compound

Product 1

HCID 67973726HCID 67973726, compound

Procedure

The compound was prepared from (R)-(2-hydroxy-1-methyl-ethyl)-carbamic acid tert-butyl ester and 5-phenoxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester using the methods described in the preceding examples 7 ((rac)-2-(2-tert-butoxycarbonylamino-propyl)-5-phenoxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester) and 6 (2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one).

Sources & evidence

ORD record
ord-8a368233432544ee9163cdbdeebd1693
Source dataset
uspto-grants-2013_11
Patent number
US08592422B2

Reaction notes

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