tert-Butyl 2-hydroxy-2-methylpropylcarbamate → HCID 67974329, compound

HRID 2046173Notes

Reaction equation

HRID 2046173 reaction equation
C(O[C:4]([C:6]1[NH:7][N:8]=[C:9]([CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:10]=1)=[O:5])C.O[C:20]([CH3:31])([CH3:30])[CH2:21][NH:22]C(=O)OC(C)(C)C.C(OC(C1N(CC(NC(OC(C)(C)C)=O)C)N=C(COC2C=CC=CC=2)C=1)=O)C.O(CC1C=C2C(=O)NCCN2N=1)C1C=CC=CC=1>>[CH3:30][C:20]1([CH3:31])[N:7]2[N:8]=[C:9]([CH2:11][O:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:10]=[C:6]2[C:4](=[O:5])[NH:22][CH2:21]1

Participants

5

Reactant 4

HCID 11106129tert-Butyl 2-hydroxy-2-methylpropylcarbamateHCID 57411799HCID 57411799, compoundHCID 67958408ethyl 1-{2-[(tert-butoxycarbonyl)amino]propyl}-3-(phenoxymethyl)-1H-pyrazole-5-carboxylateHCID 178469067HCID 178469067, compound

Product 1

HCID 67974329HCID 67974329, compound

Procedure

The compound was prepared from 5-phenoxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester and tert-butyl (2-hydroxy-2-methylpropyl)carbamate using the methods described in the preceding examples 7 ((rac)-2-(2-tert-butoxycarbonylamino-propyl)-5-phenoxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester) and 6 (2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one).

Sources & evidence

ORD record
ord-a03cfde14934426a8af2fb05e65f7a00
Source dataset
uspto-grants-2013_11
Patent number
US08592422B2

Reaction notes

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