Acetonitrile → HCID 67975786, compound

Participants

Reaction Conditions

Reaction Steps

Manganese dioxide (0.36 g, 4.1 mmol) was added to a stirred solution of 2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one (0.10 g, 0.41 mmol) in toluene (5 mL). The mixture was stirred at 120° C. for 10 hours and then filtered through a pad of diatomaceous earth and washed with MeOH and AcOEt. The solvents were evaporated in vacuo and the crude product purified by RP HPLC on (C18 XBridge 30×100 5 um). Mobile phase (Gradient from 80% 0.1% NH4CO3H/NH4OH pH 9 solution in H2O, 20% ACN to 0% 0.1% NH4CO3H/NH4OH pH 9 solution in H2O, 100% ACN) to yield 2-phenoxymethyl-5H-pyrazolo[1,5-a]pyrazin-4-one (4.71 mg, 4.6% yield) as a solid.

Provenance & Evidence