HCID 57411801, compound → HCID 57411803, compound

Participants

Reaction Steps

A solution of 7-(4-fluoro-phenyl)-2-phenoxymethyl-7H-[1,2,4]triazolo[1,5-a]pyrazin-8-one (26 mg, 0.08 mmol) in a mixture of DCM (1 mL) and MeOH (1 mL) was hydrogenated in a H-Cube reactor (1.0 mL/min, 30 mm Pd/C 10% cartridge, full H2 mode, 100° C., 3 cycles). The solvent was evaporated in vacuo and the residue was purified by RP HPLC, mobile phase (gradient from 80% 0.1% NH4CO3H pH=7.8 solution in H2O, 20% MeOH to 0% 0.1% NH4CO3H pH=7.8 solution in H2O, 100% MeOH) to yield 7-(4-fluoro-phenyl)-2-phenoxymethyl-6,7-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazin-8-one (1.7 mg, 6% yield). 1H NMR (400 MHz, CDCl3) δ ppm 4.11-4.24 (m, 2H), 4.44-4.58 (m, 2H), 5.42 (s, 2H), 6.95-7.02 (m, 2H), 7.04 (t, J=7.4 Hz, 1H), 7.13 (t, J=8.6 Hz, 2H), 7.29-7.49 (m, 4H).

Provenance & Evidence