HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Oxalate → 2-(4-fluoro-phenoxymethyl)-6,7-Dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Oxalate | HCID 7268 | — |
| Reactant | 1-(4-Fluorophenoxy)propan-2-one | HCID 12814694 | — |
| Reactant | HCID 57411799 | HCID 57411799 | — |
| Reactant | 2,4-Dioxo-5-phenoxy-pentanoic acid ethyl ester | HCID 57435086 | — |
| Reactant | ethyl 1-{2-[(tert-butoxycarbonyl)amino]propyl}-3-(phenoxymethyl)-1H-pyrazole-5-carboxylate | HCID 67958408 | — |
| Reactant | HCID 178469067 | HCID 178469067 | — |
| Product | 2-(4-fluoro-phenoxymethyl)-6,7-Dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one | HCID 67974478 | — |
Reaction Steps
The compound was prepared from 1-(4-fluoro-phenoxy)-propan-2-one and diethyl oxalate using the methods described in the preceding examples 3 (2,4-dioxo-5-phenoxy-pentanoic acid ethyl ester), 4 (5-phenoxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester), 7 ((rac)-2-(2-tert-butoxycarbonylamino-propyl)-5-phenoxymethyl-2H-pyrazole-3-carboxylic acid ethyl ester) and 6 (2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592422B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-9ed0eb1130544ea3b53660dacfab41c0 |
| Source note | uspto-grants-2013_11 |