HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-6-hydroxymethyl-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one → (R)-2-Phenoxymethyl-6-trimethylsilanyloxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-6-hydroxymethyl-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one | HCID 67974237 | — |
| Reactant | HCID 67976039 | HCID 67976039 | — |
| Reactant | (R)-4-(5-ethoxycarbonyl-3-phenoxymethyl-pyrazol-1-ylmethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester | HCID 70654332 | — |
| Product | (R)-2-Phenoxymethyl-6-trimethylsilanyloxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one | HCID 70654437 | — |
Reaction Steps
The compound was prepared from (R)-4-(5-ethoxycarbonyl-3-phenoxymethyl-pyrazol-1-ylmethyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester using the methods described in the preceding examples 31 ((S)-6-hydroxymethyl-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one) and 32 ((S)-2-phenoxymethyl-6-trimethylsilanyloxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592422B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-3730b334cb7d4ef7a2d4332e0584ff8f |
| Source note | uspto-grants-2013_11 |