HRID20462

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)N[C@@H](Cc1cc(F)cc(Br)c1)[C@H](O)[C@H]1CO[C@@H](OCC(C)(C)C)[C@H](C)N1C(=O)OC(C)(C)C

HCID68561702

未命名化合物

HCID178445882

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N[C@@H](Cc1cc(F)cc(CCC(C)C)c1)[C@H](O)[C@H]1CO[C@@H](OCC(C)(C)C)[C@H](C)N1C(=O)OC(C)(C)C

HCID68560172

未命名化合物

收率 78%

PROCEDURE

实验过程

Beginning with 3-methylbutyl zinc bromide and (2R,3S,5R)-5-[(1S,2S)-1-hydroxy-2-acetylamino-3-(3-bromo-5-fluorophenyl)-propyl]-2-(2,2-dimethylpropoxy)-3-methylmorpholine-4-carboxylic acid tert-butyl ester (0.165 g, 0.287 mmol), the title compound (0.127 g, 78%) may be prepared essentially as described in Preparation 409.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ef9a4bf29eb5429b9b82e53f73b17f58
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07745438B2
来源说明: uspto-grants-2010_06

反应 SMILES

[Br-].[CH3:2][CH:3]([CH3:7])[CH2:4][CH2:5][Zn+].[C:8]([O:12][C:13]([N:15]1[C@@H:20]([C@@H:21]([OH:36])[C@@H:22]([NH:32][C:33](=[O:35])[CH3:34])[CH2:23][C:24]2[CH:29]=[C:28]([F:30])[CH:27]=[C:26](Br)[CH:25]=2)[CH2:19][O:18][C@@H:17]([O:37][CH2:38][C:39]([CH3:42])([CH3:41])[CH3:40])[C@@H:16]1[CH3:43])=[O:14])([CH3:11])([CH3:10])[CH3:9]>>[C:8]([O:12][C:13]([N:15]1[C@@H:20]([C@@H:21]([OH:36])[C@@H:22]([NH:32][C:33](=[O:35])[CH3:34])[CH2:23][C:24]2[CH:25]=[C:26]([CH2:5][CH2:4][CH:3]([CH3:7])[CH3:2])[CH:27]=[C:28]([F:30])[CH:29]=2)[CH2:19][O:18][C@@H:17]([O:37][CH2:38][C:39]([CH3:42])([CH3:41])[CH3:40])[C@@H:16]1[CH3:43])=[O:14])([CH3:11])([CH3:10])[CH3:9]