5-cyclopropylmethyl-2-hydroxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one → 5-(4-Fluoro-phenyl)-2-hydroxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

HRID 2046208Notes

Reaction equation

HRID 2046208 reaction equation
C([O:3][C:4]([C:6]1[CH:22]=[C:9]2[C:10](=[O:21])[N:11]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)[CH2:12][CH2:13][N:8]2[N:7]=1)=O)C.C1(CN2CCN3N=C(CO)C=C3C2=O)CC1>>[F:20][C:17]1[CH:18]=[CH:19][C:14]([N:11]2[CH2:12][CH2:13][N:8]3[N:7]=[C:6]([CH2:4][OH:3])[CH:22]=[C:9]3[C:10]2=[O:21])=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 679759505-cyclopropylmethyl-2-hydroxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-oneHCID 679759865-(4-Fluorophenyl)-4-oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester

Product 1

HCID 679743405-(4-Fluoro-phenyl)-2-hydroxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Procedure

The compound was prepared from 5-(4-fluorophenyl)-4-oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester using the method described in the preceding example 50 (5-cyclopropylmethyl-2-hydroxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one.

Sources & evidence

ORD record
ord-653f894beebc43198c3edecb8acad9b3
Source dataset
uspto-grants-2013_11
Patent number
US08592422B2

Reaction notes

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