HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methyloxybenzyl chloride → 2-Hydroxymethyl-5-(4-methoxy-benzyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| Reactant | Ethyl 5-(cyclopropylmethyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate | HCID 58465837 | — |
| Reactant | 5-cyclopropylmethyl-2-hydroxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one | HCID 67975950 | — |
| Product | 2-Hydroxymethyl-5-(4-methoxy-benzyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one | HCID 67974437 | — |
Reaction Steps
The compound was prepared from 1-(3-tert-butoxycarbonylaminoethyl)-1H-pyrazole-3,5-dicarboxylic acid diethyl ester and 4-methoxybenzyl chloride using the methods described in the preceding examples 49 (5-cyclopropylmethyl-4-oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester) and 50 (5-cyclopropylmethyl-2-hydroxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592422B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-d23c1dbd09d045ee81e3c141701e284c |
| Source note | uspto-grants-2013_11 |