2-Bromo-5-fluoropyridine → Acetic acid 5-(5-fluoro-pyridin-2-yl)-4-oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-2-ylmethyl ester

HRID 2046215Notes

Reaction equation

HRID 2046215 reaction equation
[O:1]=[C:2]1[NH:7][CH2:6][CH2:5][N:4]2[N:8]=[C:9]([CH2:11][O:12][C:13](=[O:15])[CH3:14])[CH:10]=[C:3]12.Br[C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][N:18]=1.FC1C=C(F)C=CC=1N1CCN2N=C(COC3C=CC=CC=3)C=C2C1=O>>[F:23][C:20]1[CH:21]=[CH:22][C:17]([N:7]2[CH2:6][CH2:5][N:4]3[N:8]=[C:9]([CH2:11][O:12][C:13](=[O:15])[CH3:14])[CH:10]=[C:3]3[C:2]2=[O:1])=[N:18][CH:19]=1

Participants

4

Reactant 3

HCID 27831712-Bromo-5-fluoropyridineHCID 57411802HCID 57411802, compoundHCID 67974158Acetic acid 4-oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-2-ylmethyl ester

Product 1

HCID 67975679Acetic acid 5-(5-fluoro-pyridin-2-yl)-4-oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-2-ylmethyl ester

Procedure

The compound was prepared from acetic acid 4-oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-2-ylmethyl ester and 2-bromo-5-fluoropyridine using the method described in the preceding example 43 (5-(2,4-difluoro-phenyl)-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one).

Sources & evidence

ORD record
ord-cefadbea73414dec9831e3463afec996
Source dataset
uspto-grants-2013_11
Patent number
US08592422B2

Reaction notes

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