反应详情

Potassium carbonate (63 mg, 0.46 mmol) was added to a stirred suspension of acetic acid 5-(5-fluoro-pyridin-2-yl)-4-oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazin-2-ylmethyl ester (70 mg, 0.23 mmol) in MeOH (1 mL). The mixture was stirred at room temperature for 16 hours. The solvent was evaporated in vacuo. The crude product was purified by flash column chromatography (silica, 7 N solution of ammonia in MeOH in DCM 0/100 to 10/90). The desired fractions were collected and the solvents evaporated in vacuo to yield 5-(5-fluoro-pyridin-2-yl)-2-hydroxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one (30 mg, 50% yield) as a white solid.

1. customThe solvent was evaporated in vacuo
2. customThe crude product was purified by flash column chromatography (silica, 7 N solution of ammonia in MeOH in DCM 0/100 to 10/90)
3. customThe desired fractions were collected
4. customthe solvents evaporated in vacuo