3-Chloro-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one → 3-Methyl-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

HRID 2046237Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[C:15]([CH3:16])=[C:9]2[C:10](=[O:14])[NH:11][CH2:12][CH2:13][N:8]2[N:7]=1)=O)[CH3:2].Cl[C:18]1[C:19](CO)=NN2CCN[C:23](=O)[C:22]=12.ClC1C(COC2C=CC=CC=2)=NN2CCNC(=O)C=12>>[CH3:16][C:15]1[C:6]([CH2:4][O:3][C:1]2[CH:23]=[CH:22][CH:18]=[CH:19][CH:2]=2)=[N:7][N:8]2[CH2:13][CH2:12][NH:11][C:10](=[O:14])[C:9]=12

Participants

Reactant 3

HCID 679745123-Chloro-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

HCID 67975593HCID 67975593, compound

HCID 679760143-Chloro-2-(hydroxymethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one

Product 1

HCID 679744943-Methyl-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

Procedure

The compound was prepared from 3-methyl-4-oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester using the methods described in the preceding examples 77 (3-chloro-2-hydroxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one) and 78 (3-chloro-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one).

Sources & evidence

ORD record: ord-267a1fe89512412bb022e4d3bc58dbd7
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592422B2

Reaction notes

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